Publications

2024

A syngeneic spontaneous zebrafish model of tp53-deficient, EGFRviii, and PI3KCAH1047R-driven glioblastoma reveals inhibitory roles for inflammation during tumor initiation and relapse in vivo.

Weiss A, D’Amata C, Pearson BJ*, Hayes MN*

eLife. 2024.

Planarians require ced-12/elmo-1 to clear dead cells by excretion through the gut.

Lindsay-Mosher N, Lusk S, Pearson BJ

Cell Reports. 2024; 43(1):113621.

2023

The BAF chromatin remodeling complex licenses planarian stem cells access to ectodermal and mesodermal cell fates.

Wiggans M, Zhu SJ, Molinaro AM, Pearson BJ

BMC Biology. 2023; 21(1):227.

aristaless-like homeobox-3 is wound induced and promotes a low-Wnt environment required for planarian head regeneration.

Akheralie Z, Scidmore TJ, Pearson BJ

Development. 2023; 150(18):dev201777.

2021

The DEAD-box helicase DDX56 is a highly-conserved stemness regulator in normal and cancer stem cells.

Pryszlak M*, Wiggans M*, Chen X, Jaramillo JE, Burns SE, Richards L, Pugh TJ, Kaplan DR, Huang X, Dirks PB, Pearson BJ

Cell Reports. 2021; 34(13):108903.

TOR is required for injury-induced activation of slow-cycling neoblasts in planarians.

Alyssa M. Molinaro, Nicole Lindsay-Mosher, and Bret J. Pearson

EMBO Reports. 2021.

2020

One Stem Cell to Rule Them All?

Mallory Wiggans and Bret J. Pearson

FEBS Journal. 2020.

An optimized QF-binary expression system for use in zebrafish.

Jason Burgess, Jeffrey T. Burrows, Roshan Sadhak, Sharon Chiang, Alex Weiss, Cassandra D’Amata, Alyssa M. Molinaro, Shujun Zhu, Michael Long, Chun Hu, Ramil Noche, James Dowling, Henry M. Krause, Bret J. Pearson

Developmental Biology. 2020; 465(2):144–56.

A novel taxon of monosegmented double-stranded RNA viruses endemic to triclad flatworms.

Jeffrey Burrows, Delphine Depierreux, Max L. Nibert, and Bret J. Pearson

Journal of Virology. 2020; 94:e00623-20.

Planarian EGF-repeat containing genes megf6 and hemicentin are required to restrict the stem cell compartment.

Nicole Lindsay-Mosher, Andy Chan, and Bret J. Pearson

PLoS Genetics. 2020; 16(2):e1008613.

2018

Smed-myb-1 specifies early temporal identity during planarian epidermal differentiation.

Zhu SJ, Pearson BJ

Cell Reports. 2018; 25:38.

Comparative transcriptomic analyses and single-cell RNA sequencing of the freshwater planarian Schmidtea mediterranea identify major cell types and pathway conservation.

Swapna LS, Molinaro AM, Lindsay-Mosher N, Pearson BJ, Parkinson J

Genome Biology. 2018; 19(1):124.

The true colours of the flatworm: mechanisms of pigment biosynthesis and pigment cell lineage development in planarians.

Lindsay-Mosher N, Pearson BJ

Seminars in Cell and Developmental Biology. 2018.

Myths vs. FACS: what do we know about planarian stem cell lineages?

Molinaro AM, Pearson BJ

Int J Dev Biol. 2018; 62(6-7-8):527–535.

The planarian TCF/LEF factor Smed-tcf1 is required for the regeneration of dorsal-lateral neuronal subtypes.

Brown DDR, Molinaro AM, Pearson BJ

Developmental Biology. 2018; 433(2):374–383.

2017

FOX and ETS family transcription factors regulate the pigment cell lineage in planarians.

He X, Lindsay-Mosher N, Li Y, Molinaro AM, Pellettieri J, Pearson BJ

Development. 2017; 144(24):4540–4551.

Yorkie is required to restrict the injury responses in planarians.

Lin AYT, Pearson BJ

PLoS Genetics. 2017; 13(7):e1006874.

A Brain Unfixed: Unlimited Neurogenesis and Regeneration of the Adult Planarian Nervous System.

Brown DDR, Pearson BJ

Frontiers in Neuroscience. 2017; 11:289.

Nervous system development and regeneration in freshwater planarians.

Ross KG, Currie KW, Pearson BJ, Zayas RM

Wiley Interdisciplinary Reviews: Developmental Biology. 2017; 6(3).

2016

Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain.

Currie KW, Molinaro AM, Pearson BJ

eLife. 2016; 5.

(Neo)blast from the past: new insights into planarian stem cell lineages.

Zhu SJ, Pearson BJ

Current Opinion in Genetics & Development. 2016; 40:74–80.

Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias.

Stubenhaus BM, Dustin JP, Neverett ER, Beaudry MS, Nadeau LE, Burk-McCoy E, He X, Pearson BJ, Pellettieri J

eLife. 2016; 5.

In silico lineage tracing through single cell transcriptomics identifies a neural stem cell population in planarians.

Molinaro AM, Pearson BJ

Genome Biology. 2016; 17:87.

HOX gene complement and expression in the planarian Schmidtea mediterranea.

Currie KW, Brown DD, Zhu S, Xu C, Voisin V, Bader GD, Pearson BJ

EvoDevo. 2016; 7:7.

2015

A mex3 homolog is required for differentiation during planarian stem cell lineage development.

Zhu SJ, Hallows SE, Currie KW, Xu C, Pearson BJ

eLife. 2015; 4.

An in vivo requirement for the mediator subunit med14 in the maintenance of stem cell populations.

Burrows JT, Pearson BJ, Scott IC

Stem Cell Reports. 2015; 4(4):670–84.

2014

Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning.

Lin AY, Pearson BJ

Development. 2014; 141(6):1197–208.

Smed-dynA-1 is a planarian nervous system specific dynamin 1 homolog required for normal locomotion.

Talbot JA, Currie KW, Pearson BJ, Collins EM

Biology Open. 2014; 3(7):627–34.

2013

Transcription factors lhx1/5-1 and pitx are required for the maintenance and regeneration of serotonergic neurons in planarians.

Currie KW, Pearson BJ

Development. 2013; 140(17):3577–88.

The Retinoblastoma pathway regulates stem cell proliferation in freshwater planarians.

Zhu SJ, Pearson BJ

Dev Biol. 2013; 373(2):442–52.

Genome-wide analysis of the bHLH gene family in planarians identifies factors required for adult neurogenesis and neuronal regeneration.

Cowles MW, Brown DD, Nisperos SV, Stanley BN, Pearson BJ, Zayas RM

Development. 2013; 140(23):4691–702.

2012

A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals.

Labbé RM, Irimia M, Currie KW, Lin A, Zhu SJ, Brown DD, Ross EJ, Voisin V, Bader GD, Blencowe BJ, Pearson BJ

Stem Cells. 2012; 30(8):1734–45.

Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms.

Bocchinfuso DG, Taylor P, Ross E, Ignatchenko A, Ignatchenko V, Kislinger T, Pearson BJ, Moran MF

Mol Cell Proteomics. 2012; 11(9):681–91.

TORC1 is required to balance cell proliferation and cell death in planarians.

Tu KC, Pearson BJ, Sánchez Alvarado A

Dev Biol. 2012; 365(2):458–69.

2010

A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages.

Pearson BJ, Sánchez Alvarado A

Development. 2010; 137(2):213–21.

2009

Formaldehyde-based whole-mount in situ hybridization method for planarians.

Pearson BJ, Eisenhoffer GT, Gurley KA, Rink JC, Miller DE, Sánchez Alvarado A

Dev Dyn. 2009; 238(2):443–50.

2008

Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling.

Oviedo NJ, Pearson BJ, Levin M, Sánchez Alvarado A

Dis Model Mech. 2008; 1(2-3):131–43.

Regeneration, stem cells, and the evolution of tumor suppression.

Pearson BJ, Sánchez Alvarado A

Cold Spring Harbor Symposia on Quantitative Biology. 2008; 73:565–72.

2006

Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened.

Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M

Dev Biol. 2006; 297(1):127–40.

2005

Regulation of temporal identity transitions in Drosophila neuroblasts.

Grosskortenhaus R, Pearson BJ, Marusich A, Doe CQ

Dev Cell. 2005; 8(2):193–202.

2004

Specification of temporal identity in the developing nervous system.

Pearson BJ, Doe CQ

Annu Rev Cell Dev Biol. 2004; 20:619–47. Review.

Molecular characterization, functional expression and tissue distribution of a second NCKX Na⁺/Ca²⁺-K⁺ exchanger from Drosophila.

Winkfein RJ, Pearson B, Ward R, Szerencsei RT, Colley NJ, Schnetkamp PP

Cell Calcium. 2004; 36(2):147–55.

2003

Regulation of neuroblast competence in Drosophila.

Pearson BJ, Doe CQ

Nature. 2003; 425(6958):624–8.

2002

Potassium-dependent sodium-calcium exchange through the eye of the fly.

Webel R, Haug-Collet K, Pearson B, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ

Annals of the New York Academy of Sciences. 2002; 976:300–14.

2001

Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.

Isshiki T, Pearson B, Holbrook S, Doe CQ

Cell. 2001; 106(4):511–21.

The homeobox gene lim-6 is required for distinct chemosensory representations in C. elegans.

Pierce-Shimomura JT, Faumont S, Gaston MR, Pearson BJ, Lockery SR

Nature. 2001; 410(6829):694–8.

1999

Cloning and characterization of a potassium-dependent sodium/calcium exchanger in Drosophila.

Haug-Collet K, Pearson B, Webel R, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ

The Journal of Cell Biology. 1999; 147(3):659–70.

Recruitment of a hedgehog regulatory circuit in butterfly eyespot evolution.

Keys DN, Lewis DL, Selegue JE, Pearson BJ, Goodrich LV, Johnson RL, Gates J, Scott MP, Carroll SB

Science. 1999; 283(5401):532–4.

Big Bang